Loss of 'self', or ego loss, is generally agreed to be the major effect of hallucinogenic drugs such as mescaline or LSD. Such a small amount of these drugs reaches the brain that it is generally supposed that they act as a trigger to a natural process.
Aldous Huxley wrote a book about the effects of these drugs, the title of which he took from a prose poem by William Blake a visionary not known to have used hallucinogenics.
This is the quote from William Blake's, 'The Marriage of Heaven and Hell'.
If the doors of perception were cleansed every thing would appear to man as it is, infinite.
LSD
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